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FLASH GENE
Symbol MPL contributors: mct - updated : 10-12-2015
HGNC name myeloproliferative leukemia virus oncogene
HGNC id 7217
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage hematopoietic cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two intracellular cytokine receptor box motifs containing cysteine residues receptor, transducing exclusive signals in embryonic and fetal hematopoietic cells; within the Mpl-EC domain 1 (Mpl-EC-D1), AAs 102–251 were strongly involved in ligand binding (TPO and NUDC- binding to the AA region from 206 to 251)
  • the WSXWS motif, participating in the interaction between MPL and NUDC, and may play a role in stabilizing the conformation of the receptor during cytokine binding
  • two fibronectin type 3 domains
    • mono polymer dimer
    HOMOLOGY
    intraspecies homolog to virus myeloproliferative leukemia oncogene
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 1 subfamily
    • CATEGORY protooncogene , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • may be a regulatory molecule specific for TPOR dependent immune responses
  • playing a specific role in early embryonic or fetal hematopoietic progenitors and stem cells
  • positive-selection marker for the isolation of cancer stem cells in some case of T-caute lymphoblastic leukemia (Yamazaki 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • protein constituent of transmembrane
    • INTERACTION
    DNA
    RNA
    small molecule
    protein . regulated by RUNX1, both positively and negatively by changing the binding partner according to cell types
  • receptor of thrombopoietin
  • interacts with NUDC
  • following commitment to megakaryocyte differentiation, the H3K27 demethylase KDM6B up-regulation influences both ITGA2B and MPL expression
  • CLASP2-mediated stabilization of microtubules is required for proper attachment, homing, and maintenance of hematopoietic stem cells, and this is necessary to sustain MPL transcription
  • association between ATP5F1D and the Aa98-113 domain of MPL (the dissociation of ATP5F1D from MPL after TPO stimulation suggests that ATP5F1D may be a new component of TPO signaling
  • RBM15 which associates with HDAC3 and the histone methyltransferase, SETD1B, binds to both MPL RNA and chromatin and regulates H4 acetylation and H3K4me3 marks
  • DLGAP1 is a novel, potent factor in MPL signaling, affecting megakaryocytic growth and differentiation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CAMT
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in polycythemia vera and idiopathic myelofibrosis
    tumoral     --over  
    in B precursor leukemia cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS