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FLASH GENE
Symbol MPI contributors: mct/npt - updated : 11-09-2009
HGNC name mannose phosphate isomerase
HGNC id 7216
Corresponding disease
CDG1B congenital disorder of glycosylation, type 1B
Location 15q24.1      Physical location : 75.182.409 - 75.190.565
Synonym name
  • mannosephosphate isomerase (phosphomannose isomerase 1)
  • mannose-6- phosphate isomerase
  • Synonym symbol(s) PMI, PMI1, FLJ39201
    EC.number 5.3.1.8
    DNA
    TYPE functioning gene
    STRUCTURE 8.16 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1771 - 423 - Devis (2002)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrineadrenal gland   highly
    Nervousbrain   highly
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • mannose-6-phosphate isomerase type 1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • zinc metalloenzyme that catalyzes the reversible isomerization of mannose-6-phosphate and fructose-6-phosphate (Xiao 2006)
  • playing a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS