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FLASH GENE
Symbol MBP contributors: mct/npt - updated : 19-10-2016
HGNC name myelin basic protein
HGNC id 6925
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
conjugated PhosphoP , Other
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Mbp
Homologene
FAMILY
  • myelin basic protein family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing a role in nerve function and in formation and stabilization of the myelin membrane
  • may play a role in regulating the deposition of Abeta42 and thereby also may regulate the early formation of amyloid plaques in Alzheimer's disease (Hoos 2009)
  • play roles in myelination and T cell activation pathways (Ahmed 2007)
  • acting synergistically with PMP2 to cause stacking of lipid bilayers (Suresh 2010)
  • function as a new type of modulator of intracellular Ca(2+) levels in oligodendrocyte progenitor cells (OPCs)
  • the only known structural protein required for formation of myelin, produced by oligodendrocytes in the central nervous system, is myelin basic protein (MBP)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , immunity/defense , nervous system
    text central nervous system development
    PATHWAY
    metabolism
    signaling neurotransmission
    synaptic transmission
    a component
  • major constituent of normal myelin of central nervous system
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific interaction between HSPA4 and MBP suggestive of a possible role for HSPA4 in the immunopathology associated with multiple sclerosis (Lund 2006)
  • interacting with OLIG1 and SOX10 (OLIG1 and SOX10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes) (Li 2007)
  • interaction of calmodulin with a C-terminal segment of MBP (Majava 2008)
  • regulates SOCE (store-operated Ca(2+) entry) in T-cells and oligodendrocyte precursor cells
  • binds to STIM1-ORAI1 complexes to negatively regulate the activity of SOCCs (store-operated Ca(2+) channels)
  • RNA-binding protein HNRNPF is a novel component of MBP mRNA transport granules
  • HNRNPF is a regulatory element of MBP expression in oligodendrocytes, suggesting an important function of HNRNPF in the control of myelin synthesis
  • DDX54 may directly interact with MBP mRNA
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL18QD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in multiple sclerosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS