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FLASH GENE

Symbol

MBP

contributors: mct/npt - updated : 19-10-2016

HGNC name	myelin basic protein
HGNC id	6925

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	14 isoforms produced by alternative splicing classic myelin basic protein (MBP) splice isoforms range in nominal molecular mass from 14 to 21.5 kDa, and arise from the gene in the oligodendrocyte lineage (Golli) in maturing oligodendrocytes (PMID: 23398367)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 2 - splicing 1260 isoform 2 21.5 197 - 2014 24321769 also called MBP1/21.5kDa inclusion of a 26 residues sequence near the N terminus (from MBP3/18.5 kDa) using the 2nd transcription start site exon-Il-containing MBP isoform 21.5 Kda may regulate cell proliferation via a mechanism that relies on their dynamic nuclear import and export, which is not restricted to the oligodendrocyte lineage NM_002385 6 splicing 2267 NP_002376 20.2 186 central and peripheral nervous system 2014 24956930 using the 2nd transcription start site MBP2/20.2 kDa NM_001025092 5 splicing 2189 NP_001020263 17.2 160 central and peripheral nervous system 2014 24956930 absence of a 11 AAs sequence near the c terminus from (MBP3/18.5 kda using the 2nd transcription start site MBP4/17.2 kDa NM_001025101 9 splicing 2794 NP_001020272 33.1 304 fetal thymus, spleen, spinal cord and immune system 2014 24956930 using the first transcription start site 3 additional exons Golli-MBP1/HOG7 NM_001025081 7 splicing 2300 NP_001020252 26 197 fetal thymus, spleen, spinal cord and immune system 2014 24956930 Golli MBP2/HOG5 using the first transcription start site exons 1b-7 NM_001025090 6 splicing 2222 NP_001020261 18.5 171 central and peripheral nervous system 2014 24956930 using the 2nd transcription start site MBP3/18.5 kDa association of the predominant 18.5-kDa MBP isoform with cytoskeletal and signaling proteins in primary oligodendrocytes variant 1 - splicing - isoform 1 28 - tissues hematopoietic brain 2014 24956930 exons 1A-1B NM_001025100 - - 4889 NP_001020271 - 197 - 2014 24956930

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Endocrine pancreas       moderately Nervous         predominantly Reproductive male system prostate     moderately Respiratory lung       moderately Skin/Tegument skin       highly Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal     Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous oligodendrocyte

cell lineage	myeloid lineage cells
cell lines
fluid/secretion

at STAGE

physiological period

fetal

Text	thymus, spleen, spinal cord

PROTEIN

PHYSICAL PROPERTIES		basic
STRUCTURE

motifs/domains

conjugated

PhosphoP , Other

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to murine Mbp

Homologene

FAMILY

myelin basic protein family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	playing a role in nerve function and in formation and stabilization of the myelin membrane
	may play a role in regulating the deposition of Abeta42 and thereby also may regulate the early formation of amyloid plaques in Alzheimer's disease (Hoos 2009)
	play roles in myelination and T cell activation pathways (Ahmed 2007)
	acting synergistically with PMP2 to cause stacking of lipid bilayers (Suresh 2010)
	function as a new type of modulator of intracellular Ca(2+) levels in oligodendrocyte progenitor cells (OPCs)
	the only known structural protein required for formation of myelin, produced by oligodendrocytes in the central nervous system, is myelin basic protein (MBP)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , immunity/defense , nervous system

text	central nervous system development

PATHWAY

metabolism

signaling

neurotransmission

synaptic transmission

a component

major constituent of normal myelin of central nervous system

INTERACTION

DNA

RNA

small molecule

protein	specific interaction between HSPA4 and MBP suggestive of a possible role for HSPA4 in the immunopathology associated with multiple sclerosis (Lund 2006)
	interacting with OLIG1 and SOX10 (OLIG1 and SOX10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes) (Li 2007)
	interaction of calmodulin with a C-terminal segment of MBP (Majava 2008)
	regulates SOCE (store-operated Ca(2+) entry) in T-cells and oligodendrocyte precursor cells
	binds to STIM1-ORAI1 complexes to negatively regulate the activity of SOCCs (store-operated Ca(2+) channels)
	RNA-binding protein HNRNPF is a novel component of MBP mRNA transport granules
	HNRNPF is a regulatory element of MBP expression in oligodendrocytes, suggesting an important function of HNRNPF in the control of myelin synthesis
	DDX54 may directly interact with MBP mRNA

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEL18QD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in multiple sclerosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS