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FLASH GENE
Symbol MARS contributors: mct - updated : 19-05-2015
HGNC name methionine-tRNA synthetase
HGNC id 6898
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal GST-like subdomain required for its association with the multisynthetase complex
  • a catalytic Rossmann fold
  • a connective peptide
  • a KMSKS domain
  • a C-terminal alpha helix bundle domain
    • mono polymer dimer
    HOMOLOGY
    interspecies ortholog to murine Mars
    Homologene
    FAMILY class-1 aminoacyl-tRNA synthetase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • having tRNA ligase activity
  • and may be involved in amino acid activation
  • catalyzes the ligation of methionine to its cognate transfer RNA and therefore plays an essential role in protein biosynthesis
  • is a coupler of translational inhibition and DNA repair following DNA damage by releasing bound tumor suppressor EEF1E1 for its nuclear translocation
  • catalyzes the ligation of methionine to tRNA and is critical for protein biosynthesis
  • component of a multi-protein complex and catalyzes the ligation of methionine to tRNA molecules
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • provides a cytosolic anchoring site for aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (EEF1E1),
    • a potent tumor suppressor that is translocated to the nucleus for DNA repair upon DNA damage
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PALVP , CMT2U
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    causes a multi-organ disorder with greater impact on liver, bone marrow, lung and thyroid function than on neuronal function during infancy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS