Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MARS contributors: mct - updated : 19-05-2015
HGNC name methionine-tRNA synthetase
HGNC id 6898
Corresponding disease
CMT2U Charcot-Marie-Tooth disease, axonal, type 2U
PALVP pulmonary alveolar proteinosis
Location 12q13.3      Physical location : 57.881.850 - 57.910.432
Synonym name methionine tRNA ligase
Synonym symbol(s) METRS, MTRNS, CMT2U, ILFS2, MRS, SPG70
EC.number 6.1.1.10
DNA
TYPE functioning gene
STRUCTURE 28.70 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 2932 - 900 - 2004 15274629
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Nervousbrain    
Reproductivefemale systemuteruscervix highly
 male systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal GST-like subdomain required for its association with the multisynthetase complex
  • a catalytic Rossmann fold
  • a connective peptide
  • a KMSKS domain
  • a C-terminal alpha helix bundle domain
  • mono polymer dimer
    HOMOLOGY
    interspecies ortholog to murine Mars
    Homologene
    FAMILY class-1 aminoacyl-tRNA synthetase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • having tRNA ligase activity
  • and may be involved in amino acid activation
  • catalyzes the ligation of methionine to its cognate transfer RNA and therefore plays an essential role in protein biosynthesis
  • is a coupler of translational inhibition and DNA repair following DNA damage by releasing bound tumor suppressor EEF1E1 for its nuclear translocation
  • catalyzes the ligation of methionine to tRNA and is critical for protein biosynthesis
  • component of a multi-protein complex and catalyzes the ligation of methionine to tRNA molecules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • provides a cytosolic anchoring site for aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (EEF1E1),
  • a potent tumor suppressor that is translocated to the nucleus for DNA repair upon DNA damage
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PALVP , CMT2U
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    causes a multi-organ disorder with greater impact on liver, bone marrow, lung and thyroid function than on neuronal function during infancy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS