| basic FUNCTION
| cell adhesion molecule for postnatal neural development |
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inhibitor of axon extension (neurite outgrow) |
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RTN4 and MAG are differently involved in oligodendrocyte maturation , suggesting that RTN4 may influence also remyelination in pathological conditions such as multiple sclerosis  |
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detected in Schwann cells prior to the onset of myelination, suggesting its functions in the initiation of myelination |
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MAG, located in the adaxonal plasmalemma of myelin-producing cells, is known to signal to the axon and to modulate axonal caliber through phosphorylation of axonal neurofilament proteins |
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physiological roles of RTN4, MAG, OMG in processes, such as development, neuronal homeostasis, plasticity, and neurodegeneration |
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engages membrane-domain resident neuronal receptors to protect neurons from excitotoxicity, and soluble MAG mitigates excitotoxic damage |
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MAG together with other adhesion molecules such as CADM4 is important in sustaining axonal integrity |
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involved in myelin maintenance and glia-axon interaction |
