Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MAG contributors: mct - updated : 22-05-2017
HGNC name myelin associated glycoprotein
HGNC id 6783
Corresponding disease
PMLD4 Pelizaeus-Merzbacher-like disease 4
SPG75 spastic paraplegia 75, autosomal recessive
Location 19q13.12      Physical location : 35.783.037 - 35.804.707
Synonym name sialic acid-binding immunoglobulin-like lectin 4A
Synonym symbol(s) GMA, SIGLEC4, S-MAG, SIGLEC-4A, SIGLEC4A
DNA
TYPE functioning gene
STRUCTURE 21.67 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC390922 19 similar to FLJ38451 protein LOC390923 19 similar to zinc finger protein 113 LOC342885 19q13.13 similar to ABO histo-blood group B transferase DKFZp686N19164 FLJ38451 19q13.13 FLJ38451 protein KIAA1533 19q13.13 KIAA1533 SCN1B 19q13.1 sodium channel, voltage-gated, type I, beta HPN 19q13.1 hepsin (transmembrane protease, serine 1) LOC339320 19q13.13 similar to tectorin alpha precursor; Tectorin, alpha FXYD3 19q13.13 FXYD domain containing ion transport regulator 3 LGI4 19q13.12 leucine-rich repeat LGI family, member 4 FXYD1 19q13.1 FXYD domain containing ion transport regulator 1 (phospholemman) FXYD7 19q13.13 FXYD domain containing ion transport regulator 7 FXYD5 19q12-q13.1 FXYD domain containing ion transport regulator 5 FLJ25660 19q13.13 hypothetical protein FLJ25660 LISCH7 19q13.13 LISCH protein USF2 19q13.1 upstream transcription factor 2, c-fos interacting HAMP 19q13.1 hepcidin antimicrobial peptide MAG 19q13.1 myelin associated glycoprotein FLJ22814 19q13.13 hypothetical protein FLJ22814 CD22 19q13.1 CD22 antigen GPR40 19q13.1 G protein-coupled receptor 40 GPR41 19q13.1 G protein-coupled receptor 41 GPR42 19q13.1 G protein-coupled receptor 42 LOC390924 19 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) GPR43 19q13.1 G protein-coupled receptor 43 LOC388533 19 similar to KIPV467 ZD52F10 19q13.13 hypothetical gene ZD52F10 UNQ698 19q13.13 HLAR698 GAPDS 19q13.1 glyceraldehyde-3-phosphate dehydrogenase, testis-specific NIFIE14 19q13.1 seven transmembrane domain protein ATP4A 19q13.1 ATPase, H+/K+ exchanging, alpha polypeptide KIAA0841 19q13.13 KIAA0841 MGC10433 19q13.13 hypothetical protein MGC10433 LOC339321 19q13.13 hypothetical protein LOC339321 COX6B 19q13.1 cytochrome c oxidase subunit VIb UPK1A 19q12-q13.1 uroplakin 1A
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2380 69.1 626 - 2008 18941509
lacking exon 11, stop codon in exon 12
12 splicing 2425 64.2 583 - 2008 18941509
stop codon contained in exon 11
- - 2445 - 601 - 2008 18941509
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentralwhite matter   Homo sapiens
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousoligodendrocyte
NervousPurkinje cell
NervousSchwann cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
Text in Schwann cells prior to the onset of myelination
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
five extracellular Ig-like domains (four of the C2, one of the V type)
conjugated GlycoP
isoforms Precursor
HOMOLOGY
interspecies homolog to murine Mag
Homologene
FAMILY
  • sialoadhesin family, Ig superfamily
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text type 1 membrane protein
    basic FUNCTION
  • cell adhesion molecule for postnatal neural development
  • inhibitor of axon extension (neurite outgrow)
  • RTN4 and MAG are differently involved in oligodendrocyte maturation , suggesting that RTN4 may influence also remyelination in pathological conditions such as multiple sclerosis
  • detected in Schwann cells prior to the onset of myelination, suggesting its functions in the initiation of myelination
  • MAG, located in the adaxonal plasmalemma of myelin-producing cells, is known to signal to the axon and to modulate axonal caliber through phosphorylation of axonal neurofilament proteins
  • physiological roles of RTN4, MAG, OMG in processes, such as development, neuronal homeostasis, plasticity, and neurodegeneration
  • engages membrane-domain resident neuronal receptors to protect neurons from excitotoxicity, and soluble MAG mitigates excitotoxic damage
  • MAG together with other adhesion molecules such as CADM4 is important in sustaining axonal integrity
  • involved in myelin maintenance and glia-axon interaction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to sialylated glycoconjugates mediating myelin cell-cell interaction
  • interaction with RTN4R (ligand of RTN4R that limit axonal regeneration after CNS injury)
  • MAG binds to LRP1 with high affinity but failed to induce phosphorylation of NTRK1 or ERK1/2
  • ADGRV1 inhibits the ubiquitylation of MAG, thus enhancing the stability of this protein, and the calcium-binding domains of ADGRV1 are essential for this regulation
  • cell & other
    REGULATION
    Other RNF10 regulates MAG expression and is required for myelin formation
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG75 , PMLD4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyacquired 
    importance of early, effective anti-B-cell treatments for preventing progression of the anti-myelin-associated glycoprotein polyneuropathy
    ANIMAL & CELL MODELS
  • Mag-null mice displayed markedly increased seizure activity in response to intraperitoneal injection of kainic acid, an excitotoxic glutamate receptor agonist