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FLASH GENE
Symbol LYZ contributors: - updated : 08-03-2006
HGNC name lysozyme (renal amyloidosis)
HGNC id 6740
Corresponding disease
FAR2 familial amyloidosis, renal
Location 12q14-q15      Physical location : 69.742.133 - 69.748.013
EC.number 3.2.1.17
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Respiratoryrespiratory tractlarynx  highly
Visualeye   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,granule
intracellular,nucleus
text released from azurophilic granules
basic FUNCTION
  • involved in oxygen independent phagocytosis of Gram- bacteria
  • one of the anti-microbial agents found in milk, and also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FAR2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS