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FLASH GENE
Symbol LHB contributors: mct - updated : 12-10-2022
HGNC name luteinizing hormone beta polypeptide
HGNC id 6584
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY glycoprotein hormone beta chain family
CATEGORY signaling hormone
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,lumen
intracellular,cytoplasm,organelle,Golgi
basic FUNCTION
  • promoting spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • upstream region of LHB is one of the target sites for glucoprivation inducing AMPK activation, and AMPK plays a role in repressing LHB expression through the distal -2527 to -2198b region
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HH23
    Susceptibility to variation on the outcomes of in vitro fertilisation (IVF) and embryo transfer
    Variant & Polymorphism other
  • with a common genetic variant-leading in the heterozygous or homozygous type to slight but significant alterations in ovarian steroidogenesis
  • Trp8Arg polymorphism of the LHB gene has decreased bioactivity and a role on the IVF outcome
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS