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FLASH GENE
Symbol LHB contributors: mct - updated : 12-10-2022
HGNC name luteinizing hormone beta polypeptide
HGNC id 6584
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary   
 neuroendocrinepituitary   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY glycoprotein hormone beta chain family
CATEGORY signaling hormone
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,lumen
intracellular,cytoplasm,organelle,Golgi
basic FUNCTION
  • promoting spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • upstream region of LHB is one of the target sites for glucoprivation inducing AMPK activation, and AMPK plays a role in repressing LHB expression through the distal -2527 to -2198b region
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HH23
    Susceptibility to variation on the outcomes of in vitro fertilisation (IVF) and embryo transfer
    Variant & Polymorphism other
  • with a common genetic variant-leading in the heterozygous or homozygous type to slight but significant alterations in ovarian steroidogenesis
  • Trp8Arg polymorphism of the LHB gene has decreased bioactivity and a role on the IVF outcome
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS