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FLASH GENE

Symbol

LDHB

contributors: mct - updated : 15-05-2020

HGNC name	lactate dehydrogenase B
HGNC id	6541

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

LDHBD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in osteosarcoma cell lines tumoral     --low   in hepatocellular carcinoma (HCC), significantly lower than that in noncancerous tissues constitutional       loss of function may be closely related with the early onset or progression of age-related hearing loss (ARHL) constitutional     --other   increased LDHA/LDHB ratio causes high brain lactate levels, which, in turn, are predictive of aging phenotypes

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	LDHB can be considered as a prognostic marker for tumor recurrence and poor overall survival in osteosarcoma
	LDHB expression is a valuable prognostic biomarker for HCC and that low LDHB expression suggests unfavorable survival outcomes in HCC patients
Therapy target

ANIMAL & CELL MODELS

Ldhb knockout mice showed hearing loss at high frequencies, which is the typical feature of age-related hearing loss (ARHL)