motifs/domains
| polyfunctional protein, four homologous sphingolipid activator protein (SAPA, B, C, D) domains each of approximately 80 AAs |
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cysteine and proline residues, potential glycosylation sites |
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six cysteine residues, forming three disulfide bridges, that affect its structure and function  |
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C terminal signal peptide, and the first half of the C-terminus contains a motif required for its binding to sortilin and its transport to the lysosomes |
| SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytosolic
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| text
| synthesized as a 55 kDa protein in the endoplasmic reticulum, post-translationally modified to a 65 kDa glycosylated form and further glycosylated in the Golgi compartment to a 70 kDa product |
| basic FUNCTION
| required for glucosylceramide degradation |
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required for degradation of some sphyngolipids with short carbohydrate chains |
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playing a role in the process of carcinogenesis or cancer progression in the prostate |
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playing a role in ceramide metabolism |
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saposin C required for normal resistance of acid beta-glucosidase to proteolytic degradation |
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indispensable cofactor for the intralysosomal degradation of a number of sphingolipids and seem to interact directly with the specific lipid hydrolases and/or facilitate presentation of the lipid substrates to these enzymes |
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non-essential enhancer for glucosylceramide degradation |
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has multiple roles in glycosphingolipid (GSL) catabolism as well as a prominent function in CNS and axonal integrity independent of its role as an optimizer/stabilizer of acid beta-glucosidase (Sun 2010) |
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essential role played in modulating the GCase (glucosylceramidase) function |
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plays an important role in the localization/interaction of the enzyme with the lysosomal membranes |
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important for normal adult cochlear innervation and the maintenance of normal hearing |
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plays likely a role not only in the maintenance of normal hearing but also an important role in the neuronal maturation processes of the vestibular sensory epithelium and the maintenance of normal vestibular system function |
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might likely enhance estrogen receptor alpha-mediated signaling axis and play a role in breast cancer development and progression |
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might play a crucial role in Gaucher disease-related Parkinson |
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is a precursor of four sphingolipid activator proteins (saposins A-D) that are essential for lysosomal hydrolysis of sphingolipids |
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epidermal PRSS3 and CASP14 work cooperatively in PSAP processing and they thereby contribute likely to permeability barrier formation |
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multifunctional protein that plays roles both intracellularly, as a regulator of lysosomal enzyme function, and extracellularly, as a secreted factor with neuroprotective and glioprotective effects |
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is not only a house keeping lysosomal protein but an essential factor in the development and maintenance of the nervous systems and other systems of the body |
