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FLASH GENE

Symbol

RRM1

contributors: SGE/npt - updated : 15-03-2010

HGNC name	ribonucleotide reductase M1
HGNC id	10451

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in non-small cell lung cancer with good prognosis tumoral     --over   associated to overexpression of ERCC1, in lung tumor with excellent outcome

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	decreased by tranilast and may be a future novel chemotherapeutic strategy by Gemcitabine against pancreatic cancer (Mitsuno 2010)
	diagnostic marker of survival in pancreatic cancer patients. only patients with low RRM1 derive benefits from gemcitabine (Akita 2009)

ANIMAL & CELL MODELS