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FLASH GENE
Symbol RRM1 contributors: SGE/npt - updated : 15-03-2010
HGNC name ribonucleotide reductase M1
HGNC id 10451
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an ATP-cone domain
    • HOMOLOGY
    interspecies homolog to murine Rrm1 (97.6pc)
    homolog to rattus Rrm1-ps1 (87.4pc)
    Homologene
    FAMILY
  • ribonucleoside diphosphate reductase large chain family
    • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • putative metastasis suppressor (see TSG11D)
  • providing the precursors necessary for DNA synthesis
  • catalyzing the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
  • involved in tumor invasiveness and metastasis
  • involved in DNA repair during G1 phase (Niida 2010)
  • controls substrate specificity and global on/off enzyme activity
    • CELLULAR PROCESS nucleotide, replication
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    deoxyribonucleotides biosynthetic pathway
    a component
  • heterodimer of a large (M1) and a small chain (M2)
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
    • protein
  • interacts with RRM2B or RRM2
  • binding to KAT5 (Niida 2010)
    • cell & other
    REGULATION
    Other stimulated by ATP and inhibitied by dATP binding to the activity site
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-small cell lung cancer with good prognosis
    tumoral     --over  
    associated to overexpression of ERCC1, in lung tumor with excellent outcome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • decreased by tranilast and may be a future novel chemotherapeutic strategy by Gemcitabine against pancreatic cancer (Mitsuno 2010)
  • diagnostic marker of survival in pancreatic cancer patients. only patients with low RRM1 derive benefits from gemcitabine (Akita 2009)
    • ANIMAL & CELL MODELS