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FLASH GENE

Symbol

RRM1

contributors: SGE/npt - updated : 15-03-2010

HGNC name	ribonucleotide reductase M1
HGNC id	10451

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001033 19 - 3234 NP_001024 90 792 - Pavloff 1992

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Reproductive female system uterus cervix   highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an ATP-cone domain

HOMOLOGY

interspecies	homolog to murine Rrm1 (97.6pc)
	homolog to rattus Rrm1-ps1 (87.4pc)

Homologene

FAMILY

ribonucleoside diphosphate reductase large chain family

CATEGORY

enzyme , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	putative metastasis suppressor (see TSG11D)
	providing the precursors necessary for DNA synthesis
	catalyzing the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
	involved in tumor invasiveness and metastasis
	involved in DNA repair during G1 phase (Niida 2010)
	controls substrate specificity and global on/off enzyme activity

CELLULAR PROCESS	nucleotide, replication
	nucleotide, repair

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

purine/pyrimidine

signaling

deoxyribonucleotides biosynthetic pathway

a component

heterodimer of a large (M1) and a small chain (M2)

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein	interacts with RRM2B or RRM2
	binding to KAT5 (Niida 2010)

cell & other

REGULATION

Other

stimulated by ATP and inhibitied by dATP binding to the activity site

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in non-small cell lung cancer with good prognosis tumoral     --over   associated to overexpression of ERCC1, in lung tumor with excellent outcome

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	decreased by tranilast and may be a future novel chemotherapeutic strategy by Gemcitabine against pancreatic cancer (Mitsuno 2010)
	diagnostic marker of survival in pancreatic cancer patients. only patients with low RRM1 derive benefits from gemcitabine (Akita 2009)

ANIMAL & CELL MODELS