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FLASH GENE

Symbol

RRAS

contributors: mct/npt/pgu - updated : 27-09-2015

HGNC name	related RAS viral (r-ras) oncogene homolog
HGNC id	10447

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function when bone marrow progenitors are induced to differentiate into dendritic cells (DCs)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may serve as a novel prognostic marker for biliary atresia
Therapy target

ANIMAL & CELL MODELS

murine Rras(-/-) DCs have attenuated capacity to spread on fibronectin and form stable immunologic synapses with T cells