Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RBP4 contributors: mct - updated : 13-11-2024
HGNC name retinol binding protein 4, plasma
HGNC id 9922
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer monomer
HOMOLOGY
Homologene
FAMILY
  • calycin superfamily
  • lipocalin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • delivery of retinol from the liver stores to peripheral tissues
  • adipocyte-derived 'signal' that may contribute to the pathogenesis of type 2 diabetes
  • adipokine, linking glucose uptake in adipocytes with systemic insulin sensitivity
  • secreted by adipocytes, and associated with insulin resistance
  • adipocytokine that may link obesity and insulin resistance
  • RBP4 secretion was restricted to mature adipocytes, further indicating that RBP4 is strongly related to differentiation of adipocytes
  • has a robust acute effect of enhancement of NO production via stimulation of part of the PI3K/Akt/eNOS pathway and inhibition of ERK1/2 phosphorylation which results in vasodilatation
  • RBP4 and its membrane receptor STRA6 coordinate cellular retinol uptake
  • retinol-dependent metabolic function of RBP4 that may have important implications for the treatment of obesity
  • activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance)
  • circulating retinol transporter that is strongly associated with insulin resistance
  • is an adipokine that drives the development of hyperinsulinemia and type II diabetes in obesity patients
  • act as a oncogene in ovarian cancer cells
  • RBP4 is important for regulating cell differentiation, migration and invasion
  • regulates trophoblastic cell proliferation and invasion via the PI3K/AKT signaling pathway
  • major transport protein of the hydrophobic molecule retinol, also known as vitamin A, in the circulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cell to cell transport
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
  • complexing with transthyretin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • retinol binding
  • transthyretin binding prevents its loss by glumerular filtration
  • PSMB1 is a transcriptional activator of RBP4
  • retinol-free RBP4 (apo-RBP4) is a ligand that activates the STRA6 signaling cascade, inducing insulin resistance in gestational diabetes mellitus
  • cell & other
    REGULATION
    Other variants of RBP4 putatively influence the age of onset of familial amyloid polyneuropathy
    ASSOCIATED DISORDERS
    corresponding disease(s) RDCCAS , MCOPBC10
    related resource Retinal Information Network
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in type 2 diabetes
    tumoral     --low  
    silencing by methylation in esophageal squamous cell carcinoma
    constitutional     --low  
    maternal and umbilical cord serum RBP4 levels were lower in patients with preeclampsia than in normal pregnant women in the third trimester of pregnancy
    constitutional     --low  
    in familial partial lipodystrophy
    tumoral     --over  
    in ovarian cancer cells promoting cancer cell migration and proliferation
    constitutional     --over  
    in insulin resistance and contributes to increased diabetes risk
    constitutional     --over  
    in liver, subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) in morbidly obese subjects
    Susceptibility
  • to childhood obesity and cardiovascular risk factors
  • Variant & Polymorphism SNP
  • SNP rs3758538 is associated with obesity
  • Candidate gene lowering RBP4 is a new strategy for treating tye 2 diabetes
    Marker
  • RBP4 is a serum marker for ovarian cancer
  • Therapy target
    SystemTypeDisorderPubmed
    diabete  
    lowering RBP4 is a new strategy for treating tye 2 diabetes
    obesity  
    retinol-dependent metabolic function of RBP4 that may have important implications for the treatment of obesity
    neuromuscular  
    lowering RBP4 levels might serve as a promising therapeutic approach for prevention and treatment of muscle atrophy
    obesity  
    could be a molecular bridge between obesity and cancers and a potential target for treating obese cancer patients
    diabetetype 2 
    lowering RBP4 could be a new strategy for treating type 2 diabetes with diabetic retinopathy (DR)
    ANIMAL & CELL MODELS