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FLASH GENE
Symbol PZP contributors: - updated : 04-03-2006
HGNC name pregnancy-zone protein
HGNC id 9750
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Reproductivefemale systemuteruscervix  
cell lineage
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases
    • mono polymer homomer , tetramer
    HOMOLOGY
    interspecies ortholog to chimpanzee pzp
    intraspecies homolog to A2M
    Homologene
    FAMILY protease inhibitor i39 (alpha-2- macroglobulin) family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inhibiting all four classes of proteinases by a unique trapping mechanism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS