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FLASH GENE
Symbol PVR contributors: mct/npt/pgu - updated : 27-03-2014
HGNC name poliovirus receptor
HGNC id 9705
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • 3 Ig-like extracellular domains, D1-D3, where D1 is recognized by the virus
    • HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • nectin family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing an important role in cellular function, in cell adhesion and migration
  • binding of PVR with CD226 negatively regulates osteoclast formation
  • implicated in the formation of adherence junctions and enhancing cell proliferation via the stimulation of serum and platelet-derived growth factor through the Ras-Raf-MEK-ERK signaling pathway
  • at least in part, enhances the proliferation of ras-mutated cells
  • expressed on normal cells of an epithelial origin, such as endothelial cells
  • has a key role in regulating NK cell function
  • appeared to be a key ligand recognized by CD226 in NK cell-mediated suppression of metastases, and CD226-mediated suppression coincided with perforin activity
  • enhances cell migration, proliferation, and metastasis
  • cell surface protein that exert immune regulatory functions
  • IFNG-inducible immune regulatory protein on the surface of endothelial cells that attenuates the acquisition of effector functions in CD8 T cells
  • structure of TIGIT immunoreceptor bound to PVR reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding of PVR with CD226 negatively regulates osteoclast formation and cellular fusion process may be inhibited by the PVR-mediated signaling
  • interacting with CD96 (interaction may be crucial in developmental processes)
  • TIGIT, a new protein expressed by T and NK cells binds to PVR and PVR-like receptors and inhibits T cell activity indirectly through the manipulation of dendritic cells activity
  • TIGIT binds to PVR on the dendritic cell surface, driving them to a more tolerogenic phenotype
  • TIGIT is a novel inhibitory receptor, interacting with two ligands: PVR and NECTIN2 and to inhibit human NK-cell cytotoxicity
  • TIGIT/PVR engagement suppresses interferon-gamma (IFNG1) production of NK cells
  • TIGIT was selectively up-regulated on NK cells, along with high expression of its ligand, poliovirus receptor (PVR/CD155), on hepatocytes during liver regeneration
  • PVR engages the activating receptor CD226, the inhibitory receptor TIGIT, and the CD96 receptor with both activating and inhibitory functions
  • TIGIT, upon interaction with either of its two ligands, NECTIN2 or poliovirus receptor (PVR), inhibits activation of T and NK cells
    • cell & other
    REGULATION
    Other regulated by NRF1 (nuclear respiratory factor 1)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer cells has clinical significance for prognostic evaluation of patients with primary pulmonary adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS