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FLASH GENE

Symbol

PVR

contributors: mct/npt/pgu - updated : 27-03-2014

HGNC name	poliovirus receptor
HGNC id	9705

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006505 8 - 5904 NP_006496 45.2 417 brain, heart, testis 2003 12943679 variant 1 or CD155 alpha NM_001135768 8 - 5769 NP_001129240 40 372 liver, placenta 2003 12943679 variant 2 or CD155 beta NM_001135769 7 - 5745 NP_001129241 39.2 364 liver, lung 2003 12943679 CD155 gamma or variant 3 lack exon 6 NM_001135770 6 splicing 1643 NP_001129242 42.7 392 - 2003 12943679 variant 4 delta

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       liver       highly   stomach         Respiratory lung       highly

cells

System Cell Pubmed Species Stage Rna symbol not specific stromal cell Skeleton osteoclast

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	structure giving rise to spinal cord anterior motor neurons

PROTEIN

PHYSICAL PROPERTIES		globular
STRUCTURE

motifs/domains

3 Ig-like extracellular domains, D1-D3, where D1 is recognized by the virus

HOMOLOGY

Homologene

FAMILY	immunoglobulin superfamily
	nectin family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	playing an important role in cellular function, in cell adhesion and migration
	binding of PVR with CD226 negatively regulates osteoclast formation
	implicated in the formation of adherence junctions and enhancing cell proliferation via the stimulation of serum and platelet-derived growth factor through the Ras-Raf-MEK-ERK signaling pathway
	at least in part, enhances the proliferation of ras-mutated cells
	expressed on normal cells of an epithelial origin, such as endothelial cells
	has a key role in regulating NK cell function
	appeared to be a key ligand recognized by CD226 in NK cell-mediated suppression of metastases, and CD226-mediated suppression coincided with perforin activity
	enhances cell migration, proliferation, and metastasis
	cell surface protein that exert immune regulatory functions
	IFNG-inducible immune regulatory protein on the surface of endothelial cells that attenuates the acquisition of effector functions in CD8 T cells
	structure of TIGIT immunoreceptor bound to PVR reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding of PVR with CD226 negatively regulates osteoclast formation and cellular fusion process may be inhibited by the PVR-mediated signaling
	interacting with CD96 (interaction may be crucial in developmental processes)
	TIGIT, a new protein expressed by T and NK cells binds to PVR and PVR-like receptors and inhibits T cell activity indirectly through the manipulation of dendritic cells activity
	TIGIT binds to PVR on the dendritic cell surface, driving them to a more tolerogenic phenotype
	TIGIT is a novel inhibitory receptor, interacting with two ligands: PVR and NECTIN2 and to inhibit human NK-cell cytotoxicity
	TIGIT/PVR engagement suppresses interferon-gamma (IFNG1) production of NK cells
	TIGIT was selectively up-regulated on NK cells, along with high expression of its ligand, poliovirus receptor (PVR/CD155), on hepatocytes during liver regeneration
	PVR engages the activating receptor CD226, the inhibitory receptor TIGIT, and the CD96 receptor with both activating and inhibitory functions
	TIGIT, upon interaction with either of its two ligands, NECTIN2 or poliovirus receptor (PVR), inhibits activation of T and NK cells

cell & other

REGULATION

Other

regulated by NRF1 (nuclear respiratory factor 1)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in cancer cells has clinical significance for prognostic evaluation of patients with primary pulmonary adenocarcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS