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FLASH GENE
Symbol PVR contributors: mct/npt/pgu - updated : 27-03-2014
HGNC name poliovirus receptor
HGNC id 9705
DNA
TYPE virus associated
STRUCTURE 19.62 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 5904 45.2 417 brain, heart, testis 2003 12943679
variant 1 or CD155 alpha
8 - 5769 40 372 liver, placenta 2003 12943679
variant 2 or CD155 beta
7 - 5745 39.2 364 liver, lung 2003 12943679
  • CD155 gamma or variant 3
  • lack exon 6
    • 6 splicing 1643 42.7 392 - 2003 12943679
    variant 4 delta
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     liver   highly
     stomach    
    Respiratorylung   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificstromal cell
    Skeletonosteoclast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text structure giving rise to spinal cord anterior motor neurons
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • 3 Ig-like extracellular domains, D1-D3, where D1 is recognized by the virus
    • HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • nectin family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing an important role in cellular function, in cell adhesion and migration
  • binding of PVR with CD226 negatively regulates osteoclast formation
  • implicated in the formation of adherence junctions and enhancing cell proliferation via the stimulation of serum and platelet-derived growth factor through the Ras-Raf-MEK-ERK signaling pathway
  • at least in part, enhances the proliferation of ras-mutated cells
  • expressed on normal cells of an epithelial origin, such as endothelial cells
  • has a key role in regulating NK cell function
  • appeared to be a key ligand recognized by CD226 in NK cell-mediated suppression of metastases, and CD226-mediated suppression coincided with perforin activity
  • enhances cell migration, proliferation, and metastasis
  • cell surface protein that exert immune regulatory functions
  • IFNG-inducible immune regulatory protein on the surface of endothelial cells that attenuates the acquisition of effector functions in CD8 T cells
  • structure of TIGIT immunoreceptor bound to PVR reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding of PVR with CD226 negatively regulates osteoclast formation and cellular fusion process may be inhibited by the PVR-mediated signaling
  • interacting with CD96 (interaction may be crucial in developmental processes)
  • TIGIT, a new protein expressed by T and NK cells binds to PVR and PVR-like receptors and inhibits T cell activity indirectly through the manipulation of dendritic cells activity
  • TIGIT binds to PVR on the dendritic cell surface, driving them to a more tolerogenic phenotype
  • TIGIT is a novel inhibitory receptor, interacting with two ligands: PVR and NECTIN2 and to inhibit human NK-cell cytotoxicity
  • TIGIT/PVR engagement suppresses interferon-gamma (IFNG1) production of NK cells
  • TIGIT was selectively up-regulated on NK cells, along with high expression of its ligand, poliovirus receptor (PVR/CD155), on hepatocytes during liver regeneration
  • PVR engages the activating receptor CD226, the inhibitory receptor TIGIT, and the CD96 receptor with both activating and inhibitory functions
  • TIGIT, upon interaction with either of its two ligands, NECTIN2 or poliovirus receptor (PVR), inhibits activation of T and NK cells
    • cell & other
    REGULATION
    Other regulated by NRF1 (nuclear respiratory factor 1)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer cells has clinical significance for prognostic evaluation of patients with primary pulmonary adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS