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FLASH GENE
Symbol PRKCG contributors: mct - updated : 19-05-2015
HGNC name protein kinase C, gamma
HGNC id 9402
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four conserved domains, with C terminal regulatory domains
  • an hinge region a ATP-binding site containing a N terminal catalytic domain, an ATP binding site
  • two zinc-dependent phorbol-ester and DAG binding domains
  • a C terminal regulatory domain
    • HOMOLOGY
    interspecies ortholog to murine Prkcc
    Homologene
    FAMILY PRK family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine kinas playing a role in in the development and/or progression of spinocerebellar ataxia
  • plays a role in food entrainment by regulating ARNTL stability
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    GRIN1/PRKCG signaling pathway may participate in the development of bone cancer pain
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CA8 is a novel important regulator of Purkinje cell dendritic development and that its expression is controlled by PRKCG activity
  • SLC6A1 negatively regulates T cell activation and survival through PRKCG-dependent signaling pathways
  • inhibitory role of HINT1 on the protein PRKCG in the brain and an impaired PRKCG-mediated phosphorylation signal in HINT1-deficient neuron
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA14
    Susceptibility to osteosarcoma, and metastatic osteosarcoma
    Variant & Polymorphism SNP rs454006 polymorphism of the PRKCG gene correlated to osteosarcoma susceptibility and might increase the risk of osteosarcoma; rs8103851 correlated to metastatic osteosarcoma and could be risk factors for metastatic osteosarcoma
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS