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FLASH GENE

Symbol

PRKCG

contributors: mct - updated : 19-05-2015

HGNC name	protein kinase C, gamma
HGNC id	9402

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	25.44 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002739 18 - 3143 NP_002730 - 697 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus         Nervous brain diencephalon hypothalamus       brain diencephalon amygdala

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four conserved domains, with C terminal regulatory domains
	an hinge region a ATP-binding site containing a N terminal catalytic domain, an ATP binding site
	two zinc-dependent phorbol-ester and DAG binding domains
	a C terminal regulatory domain

HOMOLOGY

interspecies

ortholog to murine Prkcc

Homologene

FAMILY

PRK family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	serine/threonine kinas playing a role in in the development and/or progression of spinocerebellar ataxia
	plays a role in food entrainment by regulating ARNTL stability

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

GRIN1/PRKCG signaling pathway may participate in the development of bone cancer pain

a component

INTERACTION

DNA

RNA

small molecule

protein	CA8 is a novel important regulator of Purkinje cell dendritic development and that its expression is controlled by PRKCG activity
	SLC6A1 negatively regulates T cell activation and survival through PRKCG-dependent signaling pathways
	inhibitory role of HINT1 on the protein PRKCG in the brain and an impaired PRKCG-mediated phosphorylation signal in HINT1-deficient neuron

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SCA14

Susceptibility

to osteosarcoma, and metastatic osteosarcoma

Variant & Polymorphism SNP	rs454006 polymorphism of the PRKCG gene correlated to osteosarcoma susceptibility and might increase the risk of osteosarcoma; rs8103851 correlated to metastatic osteosarcoma and could be risk factors for metastatic osteosarcoma

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS