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FLASH GENE
Symbol PRKCG contributors: mct - updated : 19-05-2015
HGNC name protein kinase C, gamma
HGNC id 9402
Corresponding disease
SCA14 spinocerebellar ataxia 14
Location 19q13.42      Physical location : 54.385.466 - 54.410.901
Synonym symbol(s) PKCG, PKCC, KPCG
EC.number 2.7.1.37/ 2.7.11.13
DNA
TYPE functioning gene
STRUCTURE 25.44 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Physical map
LOC390967 19 similar to hypothetical protein LOC147804 19q13.42 hypothetical protein LOC147804 LOC388561 19 similar to KIAA2033 protein LOC390968 19 hypothetical gene supported by AB107355; AK092652 LOC126017 19q13.42 similar to KIAA2033 protein LOC390969 19 hypothetical gene supported by BX647962 ZNF331 19q13.3-q13.4 zinc finger protein 331 LOC284379 19q13.42 similar to solute carrier family 7, member 3; amino acid transporter, cationic 3; solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 LOC390970 19 similar to DC2 protein NALP12 19q13.42 NACHT, leucine rich repeat and PYD containing 12 LOC91663 PRKCG 19q13.4 protein kinase C, gamma CACNG7 19q13.4 calcium channel, voltage-dependent, gamma subunit 7 CACNG8 19q13.4 calcium channel, voltage-dependent, gamma subunit 8 CACNG6 19q13.4 calcium channel, voltage-dependent, gamma subunit 6 UNQ3033 19q13.42 LAIR hlog OSCAR 19q13.42 osteoclast-associated receptor NDUFA3 19q13.42 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa TFPT 19q13.4 TCF3 (E2A) fusion partner (in childhood Leukemia) PRPF31 19q13.42 PRP31 pre-mRNA processing factor 31 homolog (yeast) CNOT3 19q13.4 CCR4-NOT transcription complex, subunit 3 LENG1 19q13.4 leukocyte receptor cluster (LRC) member 1 TMC4 19q13.42 transmembrane channel-like 4 LENG4 19q13.4 transmembrane channel-like 4 LENG5 19q13.4 leukocyte receptor cluster (LRC) member 5 RPS9 19q13.4 ribosomal protein S9
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3143 - 697 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus    
Nervousbraindiencephalonhypothalamus  
 braindiencephalonamygdala  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four conserved domains, with C terminal regulatory domains
  • an hinge region a ATP-binding site containing a N terminal catalytic domain, an ATP binding site
  • two zinc-dependent phorbol-ester and DAG binding domains
  • a C terminal regulatory domain
  • HOMOLOGY
    interspecies ortholog to murine Prkcc
    Homologene
    FAMILY PRK family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine kinas playing a role in in the development and/or progression of spinocerebellar ataxia
  • plays a role in food entrainment by regulating ARNTL stability
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    GRIN1/PRKCG signaling pathway may participate in the development of bone cancer pain
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CA8 is a novel important regulator of Purkinje cell dendritic development and that its expression is controlled by PRKCG activity
  • SLC6A1 negatively regulates T cell activation and survival through PRKCG-dependent signaling pathways
  • inhibitory role of HINT1 on the protein PRKCG in the brain and an impaired PRKCG-mediated phosphorylation signal in HINT1-deficient neuron
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA14
    Susceptibility to osteosarcoma, and metastatic osteosarcoma
    Variant & Polymorphism SNP rs454006 polymorphism of the PRKCG gene correlated to osteosarcoma susceptibility and might increase the risk of osteosarcoma; rs8103851 correlated to metastatic osteosarcoma and could be risk factors for metastatic osteosarcoma
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS