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FLASH GENE

Symbol

PRKCA

contributors: mct - updated : 28-04-2017

HGNC name	protein kinase C, alpha
HGNC id	9393

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DEL17Q24

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer cells may be correlated with the potential of cell migration and invasion

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed dermatology skin   activation of PRKCA is a new therapeutic strategy for non-healing wounds diabete type 1   PRKCA and PICK1 are promising therapeutic targets for diabetic nephropathy cardiovascular aquired heart failure novel therapeutic target for the treatment of heart failure

ANIMAL & CELL MODELS

	activation of two novel PKC isoforms (Prkcd and Prkce) and a classical PKC isoform (Prkca) during the development of steatohepatitis in mice fed the methionine- and choline-deficient (MCD) diet
	in Prkca(-/-) mice re-epithelialization is delayed, while in novel bitransgenic mice over-expressing constitutively active Prkca it is accelerated