SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm
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| text
| translocating to cytoplasm after autophosphorylation |
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G3BP2 and PRKCA, relocate to and co-localize in stress granules, but not to P-bodies, when cells are subjected to stress  |
| basic FUNCTION
| acting as a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme |
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playing a fundamental role in regulation of cardiac contractility and calcium handling in myocytes |
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may play a role in cell motility by phosphorylating CSPG4 |
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involved in inactivation of MAPK activity |
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involved in induction of apoptosis by extracellular and intracellular signal |
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inducing posive chemotaxis |
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regulating negatively glucose import, insulin receptor signaling pathway, protein amino acid phosphorylation, protein kinase activity |
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regulating positively inflammatory response, protein amino acid phosphorylation |
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involved in regulation of the force of heart contraction and muscle contraction |
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PRKCA and PRKCQ have overlapping functions in alloimmunoreactivity and both PRKCQ and PRKCA isotypes must be targeted to prevent organ allograft rejection |
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serving as major receptors for phorbol esters |
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nodal regulator of heart failure propensity |
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may have a pivotal role in cell signaling that modulates the differentiation and proliferation of osteoblasts |
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ARPC5 and HMMR, in addition to PRKCA, were required for migration of neointimal smooth muscle cells |
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PRKCA and PRKCB1, are involved in most platelet responses implicated in thrombus formation |
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its activation elicits a cascade of orchestrated phosphorylation events that may modulate EIF4G1 structure and control interaction with the EIF4E kinase, MKNK1 |
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important role of a novel signalling pathway mediated by PRKCA-HDAC6-CTNNB1 in controlling IRF3-mediated transcription |
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role in the regulation of stress granule formation during cellular stress |
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having a role in memory capacity in healthy subjects and in risk for posttraumatic stress disorder in genocide survivors |
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role in the regulation of stress granule formation during cellular stress |
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likely AKAP5, PRKCA, and TRPV4 channels form dynamic subcellular signaling domains that control Ca(2+) influx into arterial myocytes |
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PRKCA promotes the downregulation of VSIG4 and upregulation of ITGAM expression and TNF and IL6 production, a mechanism that may promote inflammation |
