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FLASH GENE

Symbol

PLAU

contributors: mct - updated : 12-06-2017

HGNC name	plasminogen activator, urokinase
HGNC id	9052

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q22.2      Physical location : 75.670.861 - 75.677.256
Synonym name	urokinase-type plasminogen activator
Synonym symbol(s)	UPA, URK, ATF, QPD, UPA, URK, u-PA, BDPLT5
EC.number	3.4.21.73

DNA

TYPE	functioning gene
SPECIAL FEATURE	gene in gene
text	NFKBL embedded in PLAU promoter region
STRUCTURE	6.40 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - PLAU - HOX11 - qter
Authors	Stein (93)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001145031 10 - 2680 NP_001138503 - 414 - 2014 24549574 NM_002658 11 - 2395 NP_002649 - 431 - 2014 24549574 NM_001319191 10 - 2315 NP_001306120 - 345 - 2014 24549574

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Endocrine pancreas       highly Nervous brain         Respiratory lung       highly   respiratory tract larynx       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Muscular striatum skeletal

cell lineage
cell lines
fluid/secretion	urine

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a cysteine-rich kringle domain
	one EGF-like domain

HOMOLOGY

Homologene

FAMILY

peptidase family S1

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	plasminogen activator, urokinase serine protease, involved in plasminogen activation to plasmin
	playing a role in the regulation of monocyte/macrophage functions, such as that occurring in inflammatory reactions
	critical role for PLAU in Treg suppressor function
	IL6, JUN, and PLAU may be involved in development of neuropathic pain
	is involved in cell migration, proliferation and tissue remodeling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

coagulation/hemostasis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	SP100 interacts with the ETS1 transcription factor, reduces ETS1-DNA binding and inhibits ETS1 transcriptional activity on the MMP1 and PLAU promoters
	SERPINB2 is a potent inhibitor of urokinase-type plasminogen activator (PLAU) and also acts as a multifunctional protein
	BRMS1 recruits HDAC1 to the NF-kappaB binding site of the PLAU promoter, modulates histone acetylation of RELA on the PLAU promoter, leading to reduced NF-kappaB binding activity on its consensus sequence, and reduced transactivation of PLAU expression
	mediates Treg suppressor function via STAT5 and ERK signaling pathways
	HMGA1 has a direct role in regulating the transcription of PLAU and SERPINE1 which may constitute an important mechanism by which HMGA1 promotes cancer progression
	MMD-dependent secretion of a protease, PLAU, prevents anoikis and initiates autocrine activation of a PLAU receptor/signal transducer
	activation of STING inhibits cancer cell migration and invasion by suppressing PLAU

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   could suppress tumor growth

Susceptibility

to Alzheimer disease to myocardial infarction (MI)

Variant & Polymorphism other	polymorphism increasing the risk of Alzheimer disease
	rs4065 might be a previously unknown genetic risk factor for MI

Candidate gene
Marker	can be a diagnostic and prognostic biomarker in in head and neck squamous cell carcinoma (HNSCC)
Therapy target

ANIMAL & CELL MODELS