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FLASH GENE
Symbol SERPINB2 contributors: mct - updated : 13-11-2024
HGNC name serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
HGNC id 8584
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY serpin family
CATEGORY enzyme , regulatory
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic,vesicle
text
  • delivered to the plasma membrane, apparently together with TGOLN2 in the same vesicles, which after fusion with the membranes released cargo
    • basic FUNCTION
  • serine proteinase inhibitor
  • plasminogen activator inhibitor type 2
  • inhibit extracellular matrix degradation by PLAU (urokinase inhibitor)
  • regulation of Th1 responses appears to be a physiological function of inflammation-associated SERPINB2
  • enzyme inhibitor which is involved in various biological processes including cell differentiation, tissue regrowth and regeneration
  • has a role for promoting the differentiation of epidermal keratinocytes
  • in endothelial cells SERPINB2 induced with inflammatory stimuli, can inhibit proteasome and thus tilt the balance favoring proapoptotic signaling
  • its extracellular concentration significantly increases during inflammation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protecting hematopoietic cells and keratinocytes from inappropriatly timed apoptosis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • potent inhibitor of urokinase-type plasminogen activator (PLAU) and also acts as a multifunctional protein
  • physiological interaction between RB1, RBL2 and SERPINB2
  • is a cell survival factor that modulates RB1 repression of proapoptotic signal transduction
  • while SERPINE1 and SERPINB2 function similarly in the control of cellular plasmin generation by PLAT, they may have disparate effects on the alternative functions of PLAT via modulation of its engagement with endocytosis receptors
  • interacts with proteasome and affects its activity in endothelial cells
  • SERPINB2 and TGM2 are downstream mediators in the antiapoptotic response triggered upon TBK1 activation
  • FOSB is the mediator of SERPINB2 transactivator function explaining the orientation dependence observed for SERPINB2 transactivator activity
  • FOSB and JUN can derepress transcription from the SERPINB2 promoter which may have general significance for SERPINB2-expressing cells
  • PSMB1 is part of the transcriptional machinery required for gastrin stimulated expression of SERPINB2 and REG1A, and its change in subcellular distribution in response to gastrin is consistent with this role
  • extracellular matrix-associated proteins vitronectin and plasminogen activator inhibitor-2 (SERPINB2) were identified as novel CHL1 interaction partners, promoting CHL1-induced neurite outgrowth and neuronal migration
    • cell & other
    REGULATION
    induced by high levels of expression after stimulation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in oral squamous cell carcinomas
    Susceptibility to myocardial infarction
    Variant & Polymorphism SNP
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS