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FLASH GENE
Symbol PLA2G1B contributors: - updated : 11-04-2006
HGNC name phospholipase A2, group IB (pancreas)
HGNC id 9030
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
14 cysteine residues, forming seven disulfide bonds
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • phospholipase A2, Ca2+ dependent, group 1B, inducing cell proliferation, smooth muscle contraction and lipid mediator release
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other cleaved by caspase 1 and caspase 8,for proteolysis and inactivation during apoptosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility to obesity
    Variant & Polymorphism SNP increasing the risk of obesity
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS