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FLASH GENE

Symbol

PLA2G1B

contributors: - updated : 11-04-2006

HGNC name	phospholipase A2, group IB (pancreas)
HGNC id	9030

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage
cell lines
fluid/secretion	secreted

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

14 cysteine residues, forming seven disulfide bonds

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION

phospholipase A2, Ca2+ dependent, group 1B, inducing cell proliferation, smooth muscle contraction and lipid mediator release

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

cleaved by caspase 1 and caspase 8,for proteolysis and inactivation during apoptosis

ASSOCIATED DISORDERS

corresponding disease(s)

related resource

MITOP database

Susceptibility

to obesity

Variant & Polymorphism SNP	increasing the risk of obesity

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS