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FLASH GENE
Symbol PKLR contributors: mct/npt - updated : 01-06-2009
HGNC name pyruvate kinase, liver and RBC
HGNC id 9020
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
interspecies homolog to rattus Pklr (92.6 pc)
homolog to murine Pklr (91.6 pc)
Homologene
FAMILY
  • pyruvate kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzing the production of phosphoenolpyruvate from pyruvate and ATP
  • plays an important role in the Tp53-mediated inhibition of translation under conditions of DNA damage (Yoon 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , energetic
    signaling
    final step of glycolysis
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Mg2+
  • K+
    • protein TP53 target gene and plays an important role in the tumor-suppressor function of TP53 (Yoon 2009)
    cell & other
    REGULATION
    induced by TP53 in response to the stress of DNA damage, plays an important role in the tumor-suppressor function of TP53 (Yoon 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s) PKLR , PYKH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS