Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PGK2 contributors: mct - updated : 04-06-2020
HGNC name phosphoglycerate kinase 2
HGNC id 8898
Location 6p12.3      Physical location : 49.753.365 - 49.755.053
Synonym name
  • epididymis secretory protein Li 272
  • phosphoglycerate kinase, testis specific
  • testicular tissue protein Li 139
    • Synonym symbol(s) PGK-2, PGKB, PGKPS, HEL-S-272, dJ417L20.2
    EC.number 2.7.2.3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text
  • autosomal retrogene that is expressed only during spermatogenesis (
    • STRUCTURE 1.70 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • PGK2 core promoter elements are required to direct demethylation of DNA and reconfiguration of nucleosomes, whereas both enhancer and core promoter elements are required to direct changes in histone modifications and initiation of transcription
    • MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1721 - 417 - 1996 9023984
    EXPRESSION
    Rna function mRNA is translationally regulated in the mammalian testis
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid Homo sapiens
    Reproductivespermatocyte Homo sapiens
    Reproductivespermatogonia Homo sapiens
    Reproductivespermatozoa Homo sapiens
    cell lineage specifically, in spermatogenic cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to PGK1,highly
    Homologene
    FAMILY phosphoglycerate kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in glycolysis
  • key enzyme for ATP generation
  • its expression may function solely to compensate for repressed expression of the PGK1 gene due to X-chromosome inactivation in spermatocytes
  • isozyme of the glycolytic pathway that provides ATP required for sperm motility
  • isozyme that catalyzes the first ATP-generating step in the glycolytic pathway
  • not required for the completion of spermatogenesis, but is essential for sperm motility and male fertility
  • is required for normal sperm motility and fertility in mammals
  • PGK1 and PGK2 are involved in spermatogenesis and thought to be related to sperm motility
  • GAPDHS and PGK2, two isozymes restricted to the male germline, catalyze successive steps in the glycolytic pathway in mammalian sperm
  • expression levels of GAPDHS, PGK2 and LDHC in the spermatozoa were closely correlated with progressive sperm motility
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PTBP2 (potential trans-acting factor that helps to stabilize PGK2 mRNA in male germ cells)
  • binding of PBX4, plus its coactivator PREP1, is a rate-limiting step leading to the initiation of tissue-specific transcription of the PGK2 gene
  • KHSRP serves as a decay-promoting factor for PGK2 mRNA in male germ cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    activation with others testis specific retrogenes in the ovary and ovarian cancers
    constitutional     --low  
    decreased in the testis with ageing
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a promising molecular candidate for the assessment of sperm quality and the screening of male contraceptive targets
    • Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    promising molecular candidate for the screening of male contraceptive targets
    ANIMAL & CELL MODELS