Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CHRNA3

contributors: mct - updated : 28-01-2020

HGNC name	cholinergic receptor, nicotinic, alpha polypeptide 3
HGNC id	1957

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CAKUTAD

Susceptibility

to lung cancer to alcohol dependance (Gelernter 2009) to chronic obstructive pulmonary disease (COPD) to nicotine dependence severity (NDS)

Variant & Polymorphism SNP	rs1051730
	rs578776 and rs938682 were significantly associated with the susceptibility of lung cancer
	in ever-smokers, the CHRNA3 rs1051730 genotype associated with reduced lung function and increased COPD severity
	rs660652[G] was significantly associated with nicotine dependence severity

Candidate gene	for low penetrance, high-frequency lung cancer susceptiblity genes
Marker
Therapy target

ANIMAL & CELL MODELS