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FLASH GENE
Symbol CHRNA3 contributors: mct - updated : 28-01-2020
HGNC name cholinergic receptor, nicotinic, alpha polypeptide 3
HGNC id 1957
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large N terminal extracellular domain
  • two agonist binding sites
  • four transmembrane (4TM) segments with the M2 domain comprising the cation-selective pore
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Chrna3
    homolog to murine Chrna3
    Homologene
    FAMILY
  • cholinergic receptor family
  • ligand gated ion channel family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text postsynaptic membrane
    basic FUNCTION
  • nicotinic acetylcholine-activated cation-selective channel activity
  • regulating keratinocyte chemokinesis and chemotaxis, respectively, and signaling pathways mediating these functions, having clinical implications for wound healing and control of cancer metastases
  • involved in susceptibility to alcohol dependence (Joslyn 2009)
  • mediates fast synaptic transmission in the autonomic ganglia
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by PHOX2A (regulates the promoter)
    ASSOCIATED DISORDERS
    corresponding disease(s) CAKUTAD
    Susceptibility
  • to lung cancer
  • to alcohol dependance (Gelernter 2009)
  • to chronic obstructive pulmonary disease (COPD)
  • to nicotine dependence severity (NDS)
    • Variant & Polymorphism SNP
  • rs1051730
  • rs578776 and rs938682 were significantly associated with the susceptibility of lung cancer
  • in ever-smokers, the CHRNA3 rs1051730 genotype associated with reduced lung function and increased COPD severity
  • rs660652[G] was significantly associated with nicotine dependence severity
    • Candidate gene for low penetrance, high-frequency lung cancer susceptiblity genes
    Marker
    Therapy target
    ANIMAL & CELL MODELS