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FLASH GENE
Symbol PFKP contributors: mct - updated : 04-07-2014
HGNC name phosphofructokinase, platelet
HGNC id 8878
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY phosphofructokinase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • key enzyme for the regulation of glycolysis in the brain
  • glycolytic efficiency, which is important for the survival of cancer cells, depends primarily on the preferential expression of PFKL over the PFKM and PFKP isoforms
  • plays a critical role in cell proliferation in breast cancer cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZBTB7A directly binds to the promoter and represses the transcription of critical glycolytic genes, including SLC2A3, PFKP, and PKM
    • cell & other
    REGULATION
    induced by by KLF4, playing a critical role in regulating the glycolytic metabolism of breast cancer cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS