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FLASH GENE

Symbol

PFKP

contributors: mct - updated : 04-07-2014

HGNC name	phosphofructokinase, platelet
HGNC id	8878

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10p15.2      Physical location : 3.109.751 - 3.178.995
Synonym symbol(s)	PFKF, RP11-298E9.2, FLJ40226, PFK-C
EC.number	2.7.1.11

DNA

TYPE	functioning gene
STRUCTURE	69.29 kb     22 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF
	Binding site   transcription factor
text structure	a stretch of eight adjacent putative transcription factor binding sites, seven of which are Sp-family specific sites, and an NF-Y binding site
	KLF4 binds to PFKP promoter and transactivates PFKP expression (proximal region of the PFKP promoter is a highly GC-rich region, where multiple putative KLF-binding regions exist)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002627 22 - 2657 NP_002618 - 784 - 2005 15716112 NM_001242339 24 - 2781 NP_001229268 - 776 - 2005 15716112

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive male system testis     highly Urinary kidney       highly Visual eye       highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic platelet

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

phosphofructokinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic

basic FUNCTION	key enzyme for the regulation of glycolysis in the brain
	glycolytic efficiency, which is important for the survival of cancer cells, depends primarily on the preferential expression of PFKL over the PFKM and PFKP isoforms
	plays a critical role in cell proliferation in breast cancer cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ZBTB7A directly binds to the promoter and represses the transcription of critical glycolytic genes, including SLC2A3, PFKP, and PKM

cell & other

REGULATION

induced by

by KLF4, playing a critical role in regulating the glycolytic metabolism of breast cancer cells

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS