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FLASH GENE
Symbol PFKM contributors: mct/npt - updated : 22-09-2015
HGNC name phosphofructokinase, muscle
HGNC id 8877
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer tetramer
HOMOLOGY
Homologene
FAMILY
  • phosphofructokinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • rate-limiting enzyme in glycolysis
  • muscle isoform of phosphofructokinase (PFK), which phosphorylates fructose-6-phosphate to fructose-1,6-bisphosphate, commiting glucose to glycolysis (Garcia 2009)
  • glycolytic efficiency, which is important for the survival of cancer cells, depends primarily on the preferential expression of PFKL over the PFKM and PFKP isoforms
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism energetic , monocarbon
    signaling
  • fructose metabolism
  • energy pathway
  • glucose metabolism
  • glycogen metabolism
    • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Mg2+
  • ATP
    • protein
    cell & other
    REGULATION
    activated by ADP
    AMP
    fructose bisphosphate
    inhibited by ATP
    citrate
    ASSOCIATED DISORDERS
    corresponding disease(s) GSD7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Pfkm(-/-) mice had high lethality around weaning and reduced lifespan, because of the metabolic alterations (Garcia 2009)