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FLASH GENE
Symbol PC contributors: mct - updated : 18-05-2011
HGNC name pyruvate carboxylase
HGNC id 8636
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four domains, namely, biotin carboxylase (BC), carboxyltransferase (CT), pyruvate carboxylase tetramerization (PT), and biotin carboxyl carrier protein (BCCP)
  • homotetramer with each subunit containing the three functional domains BC, CT and BCCP (PMID
    • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • nuclear-encoded mitochondrial enzyme, catalyzing the conversion of pyruvate to oxaloacetate
  • biotin-containing enzyme that catalyses the HCO(3)(-)- and MgATP-dependent carboxylation of pyruvate to form oxaloacetate
  • crucial for intermediary metabolism, controlling fuel partitioning toward gluconeogenesis or lipogenesis and in insulin secretion
  • mitochondrial enzyme that serves to supply the citric acid cycle with oxaloacetate by carboxylation of pyruvate (PMID
  • nuclear encoded protein which is actively transported into the mitochondria, and found in isolated mitochondria from human myotubes (PMID
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    a biotin covalently attached as cofactor
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCDLA
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in pancreatic islets of patients with type 2 diabetes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS