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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

XRCC1

contributors: shn/npt/pgu - updated : 19-10-2018

HGNC name	X-ray repair complementing defective repair in Chinese hamster cells 1
HGNC id	12828

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Xrcc1 null mice are morphologically abnormal (increased cell death in the epiblast and an altered morphology in the visceral embryonic endoderm) and die around embryonic day 7
	mice with neural-specific inactivation of Xrcc1 exhibit profound neuropathology characterized by loss of cerebellar interneurons and persistence of DNA strand breaks throughout the nervous system and abnormal hippocampal function