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FLASH GENE
Symbol WARS contributors: - updated : 22-02-2006
HGNC name tryptophanyl-tRNA synthetase
HGNC id 12729
Location 14q32.31      Physical location : 100.800.124 - 100.842.680
Synonym name interferon-induced protein 53
Synonym symbol(s) WARS1, GAMMA-2, IFI53, IFP53
EC.number 6.1.1.2
DNA
TYPE functioning gene
STRUCTURE 41.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map cen - SERPINA1 - D14S45 - D14S51 - D14S18 - D14S13 - WARS - D14S27 - D14S17 - D14S1 - D14S20 - D14S23 - IGHJ@ - qter
Authors Börglum (96)
Physical map
FLJ25773 14q32.31 hypothetical protein FLJ25773 RPL3P4 14 ribosomal protein L3 pseudogene 4 BCL11B 14q32.31 B-cell CLL/lymphoma 11B (zinc finger protein) FLJ23027 14q32.32 hypothetical protein FLJ23027 CCNK 14q32 cyclin K C14orf136 14q32 chromosome 14 open reading frame 136 C14orf65 14q32.31 chromosome 14 open reading frame 65 LOC390506 14 similar to RIKEN cDNA E030025D05 gene KIAA1822 14q32 KIAA1822 CYP46A1 14q32.1 cytochrome P450, family 46, subfamily A, polypeptide 1 EML1 14q32 echinoderm microtubule associated protein like 1 LOC341965 14q32.32 similar to voltage-dependent anion channel 3 RPS2P3 14 ribosomal protein S2 pseudogene 3 EVL 14q32.32 Enah/Vasp-like C14orf66 14q32.32 chromosome 14 open reading frame 66 YY1 14q32.31-q32.32 YY1 transcription factor C14orf69 14q32.32 chromosome 14 open reading frame 69 C14orf68 14 chromosome 14 open reading frame 68 WARS 14q32.31 tryptophanyl-tRNA synthetase NDUFB3P4 14q NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 4 LOC388013 14 hypothetical gene supported by BX248767 MGC4645 14q32.32 hypothetical protein MGC4645 KIAA1446 14q32.32 brain-enriched guanylate kinase-associated protein LOC388014 14 LOC388014 DLK1 14q32 delta-like 1 homolog (Drosophila) MEG3 14q32 maternally expressed 3 LOC388015 14 similar to RTl1 LOC388016 14 LOC388016 LOC388017 14 LOC388017 LOC145197 14q32.32 hypothetical LOC145197 DIO3OS 14q32.33 deiodinase, iodothyronine, type III opposite strand DIO3 14q32 deiodinase, iodothyronine, type III LOC122423 14q32.33 similar to hypothetical protein ZC477.8 - Caenorhabditis elegans LOC388018 14 LOC388018 RPL26P4 14q32.34 ribosomal protein L26 pseudogene 3 C14orf72 14q32.33 chromosome 14 open reading frame 72 PPP2R5C 14q32.2 protein phosphatase 2, regulatory subunit B (B56), gamma isoform NPM1P20 14q32.33 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 20 DNCH1 14q32-qter dynein, cytoplasmic, heavy polypeptide 1 HSPCA 14q32.33 heat shock 90kDa protein 1, alpha WDR20 14q32.33 WD repeat domain 20
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2884 - 471 - Bruneel
- - 2660 - 471 - Bruneel
- - 2488 - 430 - Bruneel
- - 2712 - 430 - Bruneel
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Reproductivefemale systemuteruscervix highly
 female systemplacenta  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION catalyzing the aminoacylation of tRNA(trp) with tryptophan
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
induced by interferon
interferon
ASSOCIATED DISORDERS
ANIMAL & CELL MODELS