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FLASH GENE

Symbol

VIM

contributors: mct/npt/pgu - updated : 30-01-2016

HGNC name	vimentin
HGNC id	12692

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CZP2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast tumor cells producing unique tubulin-based protrusions when detached from extracellular matrix and with high metastatic potential (significantly increased extension and frequency of microtubule protrusions, the tubulin microtentacles) tumoral     --low   inhibits migration and invasion of colon and breast cancer cell lines tumoral     --over   contributes to the aggressive phenotype and poor prognosis in triple-negative breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	vimentin methylation predicted poor overall survival independent of race, subtype, stage, nodal status, or metastatic disease and holds promise as a new prognostic biomarker for breast cancer patient
	changes in VIM and FBLN1 methylation levels in cell-free DNA (cfDNA) are associated with Hepatocellular carcinoma (HCC) and could represent useful plasma-based biomarkers
	positive VIM expression was shown to predict patients' relapse and poor outcome regarding patients' overall survival in laryngeal squamous cell carcinoma
Therapy target

ANIMAL & CELL MODELS