Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UCK2 contributors: mct - updated : 04-07-2023
HGNC name uridine-cytidine kinase 2
HGNC id 12562
Location 1q24.1      Physical location : 165.796.889 - 165.877.337
Synonym name uridine monophosphate kinase
Synonym symbol(s) UMK, TSA903, UK, UMPK, DKFZp686M04245
EC.number 2.7.1.44/ 2.7.1.48
DNA
TYPE functioning gene
STRUCTURE 84.01 kb     7 Exon(s)
MAPPING cloned   linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 5039 - 240 - 2004 15130468
7 - 4801 - 261 - 2004 15130468
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer tetramer
HOMOLOGY
interspecies homolog to murine Umpk
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • involved in the phosphorylation of nucleoside analogs
  • may play a role in mediating nonhumoral immunity to Hemophilus influenzae type B
  • UCK1, UCK2, play an important role in the pyrimidine salvage pathway, catalyzing the phosphorylation of uridine and cytidine to UMP and CMP, respectively
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
  • forms a tetramer in its active state, is necessary for uridine salvage
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UCK2 may play a tumor-promoting role in a catalytic independent manner by activating oncogenic signaling pathways, such as STAT3 and EGFR-AKT1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in neuroblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • UCK2 upregulation might be a valuable prognostic marker in hepatocellular carcinoma (HCC)
  • UCK2 might be a potential early diagnostic and prognostic biomarker for lung cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may serve as a potential therapeutic target for cancer treatment
    ANIMAL & CELL MODELS