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FLASH GENE

Symbol

UCK2

contributors: mct - updated : 04-07-2023

HGNC name	uridine-cytidine kinase 2
HGNC id	12562

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q24.1      Physical location : 165.796.889 - 165.877.337
Synonym name	uridine monophosphate kinase
Synonym symbol(s)	UMK, TSA903, UK, UMPK, DKFZp686M04245
EC.number	2.7.1.44/ 2.7.1.48

DNA

TYPE	functioning gene
STRUCTURE	84.01 kb     7 Exon(s)

MAPPING

cloned

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001363568 8 - 5039 NP_001350497 - 240 - 2004 15130468 NP_001350497 7 - 4801 NP_036606 - 261 - 2004 15130468

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine pancreas         Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

tetramer

HOMOLOGY

interspecies

homolog to murine Umpk

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	involved in the phosphorylation of nucleoside analogs
	may play a role in mediating nonhumoral immunity to Hemophilus influenzae type B
	UCK1, UCK2, play an important role in the pyrimidine salvage pathway, catalyzing the phosphorylation of uridine and cytidine to UMP and CMP, respectively

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

purine/pyrimidine

signaling

a component

forms a tetramer in its active state, is necessary for uridine salvage

INTERACTION

DNA

RNA

small molecule

protein

UCK2 may play a tumor-promoting role in a catalytic independent manner by activating oncogenic signaling pathways, such as STAT3 and EGFR-AKT1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in neuroblastoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	UCK2 upregulation might be a valuable prognostic marker in hepatocellular carcinoma (HCC)
	UCK2 might be a potential early diagnostic and prognostic biomarker for lung cancer
Therapy target
	System Type Disorder Pubmed cancer     may serve as a potential therapeutic target for cancer treatment

ANIMAL & CELL MODELS