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FLASH GENE
Symbol TPH1 contributors: mct/npt - updated : 10-02-2009
HGNC name tryptophan hydroxylase 1
HGNC id 12008
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ACT domain
    • mono polymer heptamer
    HOMOLOGY
    Homologene
    FAMILY
  • biopterin-dependent aromatic amino acid hydroxylase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • catalyses the rate-limiting step in the biosynthesis of serotonin (Winge 2007)
  • catalyzing the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ferrous ion
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to shizophrenia (rs1800532)
  • to heroin addiction
    • Variant & Polymorphism other association of a specific TPH1 haplotype with heroin addiction (Nielsen 2008)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS