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FLASH GENE
Symbol TPH1 contributors: mct/npt - updated : 10-02-2009
HGNC name tryptophan hydroxylase 1
HGNC id 12008
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemuterus   
Respiratorylung    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ACT domain
    • mono polymer heptamer
    HOMOLOGY
    Homologene
    FAMILY
  • biopterin-dependent aromatic amino acid hydroxylase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • catalyses the rate-limiting step in the biosynthesis of serotonin (Winge 2007)
  • catalyzing the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ferrous ion
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to shizophrenia (rs1800532)
  • to heroin addiction
    • Variant & Polymorphism other association of a specific TPH1 haplotype with heroin addiction (Nielsen 2008)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS