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FLASH GENE

Symbol

TPH1

contributors: mct/npt - updated : 10-02-2009

HGNC name	tryptophan hydroxylase 1
HGNC id	12008

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed TPH1 10 - 1335 51 444 - Nielsen (1992)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive female system uterus       Respiratory lung         Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

ACT domain

mono polymer

heptamer

HOMOLOGY

Homologene

FAMILY

biopterin-dependent aromatic amino acid hydroxylase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	catalyses the rate-limiting step in the biosynthesis of serotonin (Winge 2007)
	catalyzing the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	ferrous ion

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to shizophrenia (rs1800532) to heroin addiction

Variant & Polymorphism other	association of a specific TPH1 haplotype with heroin addiction (Nielsen 2008)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS