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FLASH GENE

Symbol

TK1

contributors: mct - updated : 09-11-2011

HGNC name	thymidine kinase 1, soluble
HGNC id	11830

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q25.1      Physical location : 76.170.159 - 76.183.285
Synonym symbol(s)	TK2
EC.number	2.7.1.21

DNA

TYPE	functioning gene
STRUCTURE	13.12 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site
text structure	Y-box sequence 5' -CTGATTGG - 3' in cis-regulatory elements
	multiple protein-binding sites
	a characteristic potential G-quadruplex-forming sequence element within the promoter of human thymidine kinase 1 (TK1)

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003258 7 - 1616 - 234 - 2004 15611477

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly Reproductive female system uterus cervix   highly   female system breast mammary gland   highly Urinary kidney tubule     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	putative upregulated c-Myc target gene
	cell-cycle-regulated enzyme of importance in nucleotide metabolism as well as an activator of antiviral and anticancer drugs such as 3'-azido-3'-deoxythymidine (AZT)
	regulatory enzyme that can interchange between its dimeric and tetrameric forms, which have low and high catalytic efficiencies, respectively
	cell cycle regulation of TK1 in normal tubule cells differ from that in other type of normal and malignant renal cells
	blood cells are less dependent on mitochondrial TK2 compared with several other tissues and these cells can synthesize deoxyribonucleotides required for mtDNA replication by alternative pathways such as phosphorylation of thymidine by cytosolic TK1
	functional contribution of thymidine kinase 1 in repair of DNA damage (
	involved in DNA synthesis and an important proliferation marker

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

reproduction/sex

PATHWAY

metabolism

purine/pyrimidine

signaling

salvage

a component

tetrameric structure in which each subunit contains an alpha/beta-domain that is similar to ATPase domains of members of the RecA structural family and a domain containing a structural zinc

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in invasive cervical carcinoma tumoral     --over   in papillary thyroid carcinoma tumoral     --over   in breast cancer tumoral     --over   its concentration is higher in patients developing distant and/or loco-regional recurrence 3 months post-surgery in breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	activity of TK1 is a useful tool for evaluating the prognosis of patients with Renal cell carcinoma
Therapy target

ANIMAL & CELL MODELS