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FLASH GENE
Symbol THY1 contributors: mct/pgu - updated : 20-10-2012
HGNC name Thy-1 cell surface antigen
HGNC id 11801
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in ovarian cancer
tumoral     --low  
in nasopharyngeal carcinoma, which is significantly associated with lymph node metastases
constitutional       gain of function
increasing neutrophil adherence in psoriasis
constitutional     --low  
in lung fibroblasts induces a fibrogenic phenotype (idiopathic pulmonary fibrosis)
Susceptibility
Variant & Polymorphism
Candidate gene candidate tumour suppressor gene in nasopharyngeal carcinoma
Marker
  • could provide a clinical prognostic marker forhepatocellular carcinoma
  • potential prognostic marker for high-grade gliomas but also a marker for cancer stem cells within gliomas
  • Therapy target
    ANIMAL & CELL MODELS