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FLASH GENE
Symbol THY1 contributors: mct/pgu - updated : 20-10-2012
HGNC name Thy-1 cell surface antigen
HGNC id 11801
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an immunoglobulin-like V-type domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Thy1
    homolog to C.elegans C48E7.7
    Homologene
    FAMILY
  • immunoglobulin superfamily
    • CATEGORY antigen , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text attached to the membrane by a GPI-anchor
    basic FUNCTION
  • playing a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain
  • putative tumor suppressor gene for ovarian cancer
  • adhesion molecule on activated endothelial cells (ECs) mediating the adhesion of neutrophils via the interaction with ITGB2
  • pivotal roles on activated dermal EC or fibroblasts and its counter receptor CD18 on neutrophils for the regulation of MMP9 and CXCL8 release from neutrophils
  • positive-selection marker for the isolation of cancer stem cells in some case of T-acute lymphoblastic leukemia
  • in myofibroblasts is not just a marker, but is a functional protein that transmits signals into the cell, up-regulating its FASLG expression
  • lymphatic vessel expressed gene, suggesting its potential role in the cell adhesion processes required for tumor progression and inflammation
  • involved in the control of inflammatory cell recruitment and, thus, also in conditioning the inflammatory microenvironment
  • functions as a tumor suppressor in ovarian cancer and in nasopharyngeal carcinoma
  • may play a critical role in the generation of tumor vasculatures in glioma via differentiation into endothelial cells
  • promoted lipofibroblast differentiation via the expression of PPARG, stimulated lipid accumulation via fatty-acid esterification, and enhanced the fatty-acid uptake mediated by fatty-acid transporter proteins
  • important in the regulation of lipofibroblast differentiation in the developing lung
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • neutrophil interaction with THY1 stimulated secretion of CXCL8 and thus could support the attraction of additional neutrophils to inflammatory sites
  • CD97, present on peripheral myeloid cells, is a novel interacting partner for THY1 (is an interacting partner for CD97 on activated endothelial cells)
  • colocalizes and coimmunoprecipitates potentially with a membrane-spanning protein HCN4 in retina
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in ovarian cancer
    tumoral     --low  
    in nasopharyngeal carcinoma, which is significantly associated with lymph node metastases
    constitutional       gain of function
    increasing neutrophil adherence in psoriasis
    constitutional     --low  
    in lung fibroblasts induces a fibrogenic phenotype (idiopathic pulmonary fibrosis)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate tumour suppressor gene in nasopharyngeal carcinoma
    Marker
  • could provide a clinical prognostic marker forhepatocellular carcinoma
  • potential prognostic marker for high-grade gliomas but also a marker for cancer stem cells within gliomas
    • Therapy target
    ANIMAL & CELL MODELS