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FLASH GENE

Symbol

THY1

contributors: mct/pgu - updated : 20-10-2012

HGNC name	Thy-1 cell surface antigen
HGNC id	11801

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	5.59 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	see BALMCR ,AT ,CD3@ ,HMBS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006288 4 - 2413 NP_006279 17 161 - 2000 1094446

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymphatic vessel       highly Homo sapiens Nervous brain       highly   nerve       highly Respiratory lung         Homo sapiens Urinary kidney       highly Visual eye retina       Rattus norvegicus

cells

System Cell Pubmed Species Stage Rna symbol not specific fibroblast Homo sapiens

cell lineage
cell lines	tumor endothelial cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an immunoglobulin-like V-type domain

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Thy1
	homolog to C.elegans C48E7.7

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

antigen , tumor suppressor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
text	attached to the membrane by a GPI-anchor

basic FUNCTION	playing a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain
	putative tumor suppressor gene for ovarian cancer
	adhesion molecule on activated endothelial cells (ECs) mediating the adhesion of neutrophils via the interaction with ITGB2
	pivotal roles on activated dermal EC or fibroblasts and its counter receptor CD18 on neutrophils for the regulation of MMP9 and CXCL8 release from neutrophils
	positive-selection marker for the isolation of cancer stem cells in some case of T-acute lymphoblastic leukemia
	in myofibroblasts is not just a marker, but is a functional protein that transmits signals into the cell, up-regulating its FASLG expression
	lymphatic vessel expressed gene, suggesting its potential role in the cell adhesion processes required for tumor progression and inflammation
	involved in the control of inflammatory cell recruitment and, thus, also in conditioning the inflammatory microenvironment
	functions as a tumor suppressor in ovarian cancer and in nasopharyngeal carcinoma
	may play a critical role in the generation of tumor vasculatures in glioma via differentiation into endothelial cells
	promoted lipofibroblast differentiation via the expression of PPARG, stimulated lipid accumulation via fatty-acid esterification, and enhanced the fatty-acid uptake mediated by fatty-acid transporter proteins
	important in the regulation of lipofibroblast differentiation in the developing lung

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	neutrophil interaction with THY1 stimulated secretion of CXCL8 and thus could support the attraction of additional neutrophils to inflammatory sites
	CD97, present on peripheral myeloid cells, is a novel interacting partner for THY1 (is an interacting partner for CD97 on activated endothelial cells)
	colocalizes and coimmunoprecipitates potentially with a membrane-spanning protein HCN4 in retina

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in ovarian cancer tumoral     --low   in nasopharyngeal carcinoma, which is significantly associated with lymph node metastases constitutional       gain of function increasing neutrophil adherence in psoriasis constitutional     --low   in lung fibroblasts induces a fibrogenic phenotype (idiopathic pulmonary fibrosis)

Susceptibility

Variant & Polymorphism

Candidate gene	candidate tumour suppressor gene in nasopharyngeal carcinoma
Marker	could provide a clinical prognostic marker forhepatocellular carcinoma
	potential prognostic marker for high-grade gliomas but also a marker for cancer stem cells within gliomas
Therapy target

ANIMAL & CELL MODELS